Center for Computational Biology and Bioinformatics
Molecular Recognition Element (MoRE)
The Center for Computational Biology and Bioinformatics brings worldclass,
cutting-edge research in these areas to Indiana with special
emphases on the problems of identifying the functions and structures of
various protein entities in a manner that stimulates both academic and
commercial collaborations.
Research at the center includes work on the relationship between intrinsic
disorder and protein function. For some proteins and especially in
eukaryotic cells, flexible, unfolded protein ensembles carry out many
biological functions. The relationships between intrinsic disorder and cell
signaling promise to redefine the modern views of cell biology.
p53 Disordered Binding Sites
Center scientists are focusing on the development and application of
computational chemistry and bioinformatics tools to important postgenomic
problems, and are studying structural wrapping and its
importance for protein interactivity and molecular disease.
Researchers at the Center for Computational Biology and Bioinformatics
use their talents in a number of research collaborations at the IU School of
Medicine and in the private sector in Indianapolis. The innovative
application of bioinformatics to study protein structure-function
relationships is yielding promising results. Novel research perspectives
have the potential to find new targets for drug discovery, to better
understand the diversity of reactions to various drug molecules, and to
develop new approaches for understanding and eliminating undesirable
side effects.