The Center for Medical Genomics at IU School of Medicine offers state-of-the-art genomic technologies for research leading to diagnoses and prognoses of diseases, prevention strategies, treatment choices and drug design.
Microarrays
The center provides microarray services from experimental design through data analysis. By centralizing these critical functions, we are able to generate consistently high quality data. Affymetrix GeneChips® allow investigators to explore the expression of nearly the entire genome at once, both in humans and in model organisms.
The center also creates custom-spotted microarrays to follow up the most interesting set of genes identified using the genomic arrays, or to study organisms for which Affymetrix GeneChips® are not available.
High-throughput SNP Genotyping
SNP (Single Nucleotide Polymorphism) genotyping provides a powerful tool to discover DNA sequence variants associated with disease risk or with drug responses.
The center uses the Sequenom MassArray®, a state-of-the-art, high throughput, MALDI-TOF mass spectrometer-based SNP genotyping system.
Bioinformatics
To manage and interpret the tremendous amount of data associated with this work, the center has developed several bioinformatics tools, including the Labrat laboratory information management system, the Microarray Data Portal, a powerful suite of microarray analysis tools, and ParSNP, which handles data generated by high-throughput SNP genotyping.
For more information on the Center for Medical Genomics, see: http://cmg.iupui.edu/cmg/home.html